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March 3, 2026Journal of Pharmaceutical Sciences

Mechanistic insights into drug loading effect on dissolution performance of Loratadine–Soluplus® amorphous solid dispersions

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Authors

JHJannat Falah HassanKAKawther Khalid AhmedTHTze Ning Hiew

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Overview

Observational analysis reveals the impact of drug loading on dissolution performance of loratadine in amorphous solid dispersions, suggesting formulation improvement strategies.

Key Points

  • Dissolution performance improves with appropriate drug loading levels in amorphous solid dispersions.
  • The study demonstrates a clear relationship between drug loading and dissolution, highlighting optimal loading at 30% for best performance.
  • Analysis of mechanistic insights was conducted on loratadine and Soluplus® solid dispersions under controlled conditions.
  • These findings may enable improved formulations in pharmaceutical applications, providing evidence for ideal loading parameters.

Cite This Study

Hassan et al. (2026) studied this question.

synapsesocial.com/papers/69a75f84c6e9836116a2af08https://doi.org/10.1016/j.xphs.2026.104188
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