Head-to-head comparative study of 68GaFAPI-04 PET/CT and 18FFDG PET/CT in assessing bone metastasis of various cancers: a systematic review and meta-analysis

Key Points

• [68Ga]FAPI-04 PET/CT shows a higher detection rate for bone metastases compared to [18F]FDG PET/CT, indicating its potential utility in cancer diagnostics.
• Significant differences in detection rates underscore the importance of choosing an appropriate imaging strategy for malignancies.
• Pooled sensitivity and specificity analyses were limited by insufficient data across studies, suggesting variability in reporting.
• The findings call for cautious interpretation, as data limitations could affect the reliability of these results.