SOCS3-siRNA-loaded exosomes derived from adipose mesenchymal stem cells promote spinal cord injury recovery through the synergy between PTEN/PI3K/AKT/mTOR and JAK2/STAT3 | Synapse
March 3, 2026
SOCS3-siRNA-loaded exosomes derived from adipose mesenchymal stem cells promote spinal cord injury recovery through the synergy between PTEN/PI3K/AKT/mTOR and JAK2/STAT3
Key Points
SOCS3-loaded exosomes promote significant recovery in spinal cord injury by modulating key molecular pathways.
Key metrics indicate a notable increase in recovery rates when PTEN and PI3K pathways are targeted alongside JAK2/STAT3 activation.
Assessment using SOCS3-siRNA-loaded exosomes derived from adipose mesenchymal stem cells shows effective cellular mechanisms for recovery.
This highlights potential therapeutic strategies for spinal cord injuries, particularly through the role of exosomes in cellular communication.