Transplantation of Skin-Derived Precursor Schwann Cells Ameliorates Secondary Brain Injury after ICH in Mice by Activating the PI3K/AKT/FOXO3a Signaling Pathway | Synapse
March 3, 2026
Transplantation of Skin-Derived Precursor Schwann Cells Ameliorates Secondary Brain Injury after ICH in Mice by Activating the PI3K/AKT/FOXO3a Signaling Pathway
Key Points
Transplantation of skin-derived precursor Schwann cells improves recovery from secondary brain injury after intracerebral hemorrhage (ICH).
Mice receiving the transplant demonstrated significant activation of the PI3K/AKT/FOXO3a signaling pathway.
Observational analysis focused on the effects of Schwann cell transplantation in a mouse model of secondary brain injury.
These findings highlight the potential of Schwann cell therapy as a treatment for brain injury, although further validation is required.