Peripheral HLA-DR+ Neutrophils, CD163+ Monocytes and Inflammatory Serum Cytokines Coincide with Severe Immune Effector Cell-Associated Neurotoxicity at Peak Toxicity Onset in CD19 CAR T cell Therapy

Key Points

• Severe neurotoxicity correlates with elevated hla-dr+ neutrophils and cd163+ monocytes, indicating immune involvement.
• Inflammatory serum cytokines also increase in tandem with immune cell activation during peak toxicity onset.
• Assessment of immune markers provides insights into neurotoxicity mechanisms related to immune cell effects on the nervous system.
• Further exploration of these associations may lead to improved monitoring and management strategies in CAR T therapy.