Polysaccharides from Baihe Dihuang decoction ameliorate depression-like behaviors in rats subjected to chronic unpredictable mild stress through modulation of metabolic homeostasis

Key Points

• Polysaccharides significantly reduce depression-like behaviors in rats under chronic unpredictable mild stress.
• The analysis showed notable behavioral improvements, indicated by decreased anxiety and depressive signs after treatment.
• This study utilizes an observational design focusing on the effects of polysaccharides on stress-induced behaviors in animal models.
• Results suggest that these polysaccharides may help restore metabolic homeostasis, warranting further exploration of their therapeutic potential.