Exposure-Response: Tacrolimus Dosing and Acute Graft Versus Host Disease in Allogeneic Hematopoietic Cell Transplant Recipients

Key Points

• Acute graft versus host disease occurs more frequently with insufficient tacrolimus dosing, affecting patient outcomes.
• Patients with lower tacrolimus levels showed a 30% higher incidence of acute graft versus host disease.
• Observational analysis on the relationship between tacrolimus dosing and immune response in transplant recipients was conducted.
• Adjusting tacrolimus dosing may reduce acute graft versus host disease, emphasizing the need for careful management.