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Allogeneic Transplantation for Older Adults with Acute Lymphoblastic Leukemia Using Pentostatin and Low-Dose Total Body Irradiation | Synapse
March 3, 2026
Allogeneic Transplantation for Older Adults with Acute Lymphoblastic Leukemia Using Pentostatin and Low-Dose Total Body Irradiation
CT
Cristian Taborda
Yale University
II
Iris Isufi
Yale Cancer Center
NB
Noffar Bar
Yale Cancer Center
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Key Points
Improved outcomes are observed following allogeneic transplantation, marking a significant step for treatment in acute lymphoblastic leukemia.
Key evidence includes the successful application of pentostatin combined with low-dose total body irradiation to enhance recovery.
The approach involved allogeneic transplantation, enabling better efficacy against acute lymphoblastic leukemia in older patients.
This highlights the need for more tailored treatments, supporting the effectiveness of combining therapies for elderly patients.
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Taborda et al. (Sun,) studied this question.
synapsesocial.com/papers/69a7606dc6e9836116a2d282
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.198
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