March 3, 2026The World Journal of Men s Health0 citationsOpen Access

ETS Homologous Factor Drives Endothelial Dysfunction in Diabetes-Related Erectile Dysfunction via Regulating SPRY1 Ubiquitination and NOS3 Autophagy

CLChunhui LiuShandong University NLNing LiuZhongda Hospital Southeast University ZYZonghao You

Key Points

Endothelial dysfunction is exacerbated by the modulation of SPRY1 and degradation of NOS3.
Key evidence shows increased SPRY1 stabilization linked to dysregulated endothelial function in diabetes.
This analysis focuses on the interaction between Ehf, SPRY1, and NOS3 in a diabetes context.
Identifying these molecular targets may lead to new treatment strategies for erectile dysfunction caused by diabetes.

Abstract

Ehf exacerbates DMED by disrupting penile endothelial function through SPRY1 stabilization and NOS3 degradation. These findings present novel molecular targets for potential therapeutic strategies in DMED.

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Cite This Study

Liu et al. (Thu,) studied this question.

synapsesocial.com/papers/69a760adc6e9836116a2da87 https://doi.org/https://doi.org/10.5534/wjmh.250095

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