Modulating the cytotoxic activity of Titanocene complexes through aliphatic chain modification to optimize albumin affinity

Key Points

• Cytotoxic activity is enhanced with specific aliphatic chain modifications, and modifications significantly improve albumin binding.
• The study shows a notable increase in albumin affinity by 30% for the optimized complexes compared to non-modified versions.
• Molecular modification analysis identifies critical structural features that correlate with improved biological activity.
• The findings highlight the potential of these titanocene complexes as more effective therapeutic agents, warranting further exploration.