Head and Neck Squamous Cell Carcinoma patient-derived Cancer-Associated Fibroblasts undergo senescence while retaining pro-tumorigenic properties after ex vivo irradiation | Synapse
March 3, 2026Open Access
Head and Neck Squamous Cell Carcinoma patient-derived Cancer-Associated Fibroblasts undergo senescence while retaining pro-tumorigenic properties after ex vivo irradiation
Key Points
Irradiated cancer-associated fibroblasts retain pro-tumorigenic properties, emphasizing their role in tumor progression.
Key evidence indicates that these fibroblasts undergo senescence, which may complicate treatment outcomes in head and neck cancer.
Observational analysis across patient-derived models highlights the need for additional therapies targeting these fibroblasts alongside radiotherapy.
Enhancing treatment strategies around fibrotic tissues may improve therapeutic responses; further studies are needed.
Abstract
This work highlights the importance of CAFs in radiotherapy and offers rationale for exploring combinations of radiotherapy and CAF-targeting approaches in HNSCC.