Synergistic pH and feast-famine regulation of polyhydroxyalkanoate biosynthesis in a methane‑oxidizing bacterium

Key Points

• Biosynthesis of polyhydroxyalkanoate is significantly influenced by both pH levels and feast-famine cycles.
• Optimal conditions lead to increased production rates, demonstrating a novel link between environmental factors and biosynthetic pathways.
• Analysis reveals that variations in pH and nutrient availability are crucial for enhancing metabolite yields in methane-oxidizing bacteria.
• Findings suggest broader implications for sustainable bioplastic production from renewable methane resources.