Multiple-testing corrections in case-control studies using identity-by-descent segments

Key Points

• Identifying the optimal multiple-testing correction leads to better statistical significance across genetic analyses.
• With identity-by-descent segments, adjustments reduce false positives in case-control studies significantly.
• Assessment using statistical methods tailored for genetic analysis enhances overall reliability and validity.
• Improving correction methods calls for ongoing refinement in statistical approaches to genetic epidemiology.