Translational Approaches for Human Pharmacokinetics and Pharmacodynamics Prediction of Antibody-drug Conjugates: Bridging Complexity from Bench to Bedside

Key Points

• Modeling of pharmacokinetics and pharmacodynamics may enable better predictions of antibody-drug conjugates' effects, enhancing therapeutic efficacy.
• With increasing complexity in drug behavior, understanding the impact of pharmacokinetics is crucial for advancing treatment protocols.
• Analysis emphasizes integrating experimental data with clinical insights for more accurate predictions in drug development.
• Highlights the need for improved translational approaches to inform clinical applications, aiming to ensure patient safety during therapy.