Decoding tumor–microbiome interplay: Mass spectrometry–driven proteomics to unveil cancer progression and therapeutic outcomes

Key Points

• Cancer progression is influenced by interactions within the tumor microenvironment and microbiome, suggesting viable intervention points.
• Key metrics demonstrate how changes in the proteome can indicate therapeutic outcomes influenced by microbial activity.
• Analysis utilizing mass spectrometry-driven proteomics across tumor samples examines this complex interplay to reveal underlying mechanisms.
• Understanding these interactions may enable the development of targeted therapies aimed at improving treatment efficacy.