March 3, 2026Canadian Journal of Cardiology1 citationsOpen Access

Clinical and angiographic outcomes following percutaneous treatment of chronic totally occluded versus non-totally occluded coronary vessels

AAAlp Aytekin FVFelix VollInterventional / Structural Cardiology FSFiorenzo Simonetti

Key Points

Higher rates of target lesion revascularization were observed at 12 months for CTO-PCI.
MI incidence was significantly lower at the same follow-up, highlighting safety aspects.

Structured PICO

Does CTO-PCI compared to non-CTO-PCI affect clinical and angiographic outcomes in patients undergoing percutaneous coronary intervention?

Population

Patients undergoing percutaneous coronary intervention for chronic totally occluded or non-totally occluded coronary vessels

Intervention

Percutaneous coronary intervention for chronic total occlusion (CTO-PCI)

Comparator

Percutaneous coronary intervention for non-totally occluded vessels (non-CTO-PCI)

Outcome

Rates of target lesion revascularization (TLR) and myocardial infarction (MI) at 12-month follow-uphard clinical

CTO-PCI is associated with higher target lesion revascularization but lower myocardial infarction rates at 12 months compared to non-CTO-PCI, alongside inferior angiographic outcomes.

Abstract

CTO-PCI was independently associated with significantly higher rates of TLR as well as a significantly lower incidence of MI at 12-month follow-up. Quantitative coronary angiography analysis of surveillance angiography showed superior angiographic outcomes after non-CTO-PCI.

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