The efficacy and mechanism of thoracic photodynamic therapy mediated by hematoporphyrin injection on disseminated pleural malignancies of Lewis lung carcinoma in mice: Am J Cancer Res. 2022; 12(4): 1502-1510

Key Points

• Thoracic photodynamic therapy notably reduced malignancies in mouse models, indicating a high efficacy.
• The study demonstrated a significant decrease in tumor size after hematoporphyrin treatment, supporting its therapeutic potential.
• Assessment using photodynamic therapy with hematoporphyrin revealed clear mechanisms underlying tumor response in Lewis lung carcinoma.
• This method highlights the potential for advancing treatment options for pleural malignancies, pending further validation.