Discovery of novel sophocarpine derivatives as potential dual Bcl-2 and Mcl-1 inhibitors: design, synthesis and anti-hepatocellular carcinoma evaluation
Novel sophocarpine derivatives effectively inhibit bcl-2 and mcl-1, showcasing potential as anti-cancer agents.
In vitro testing revealed inhibition efficacy of several derivatives against hepatocellular carcinoma cell lines.
Design and synthesis approaches focused on optimizing the molecular structure for enhanced inhibition activity.
These findings indicate a promising path for developing novel treatments for hepatocellular carcinoma, but further evaluation in clinical settings is needed.