ERRα-NOS2-mediated citrulline metabolism attenuates tubular epithelial cell senescence in diabetic kidney disease

Key Points

• Cell senescence is reduced, indicating potential for better kidney function and health.
• ERRα and NOS2 interactions showed significant effects on metabolism across experimental models.
• Study highlights the importance of citrulline metabolism in kidney disease mechanisms.
• Findings suggest that targeting this pathway may enhance treatment strategies for diabetic kidney disease.