Combining the novel all-human co-cultured hepatocytes system with physiologically based pharmacokinetic modeling to assess the translatability of cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase induction data

Key Points

• Finding supports the increased accuracy of using an all-human co-cultured hepatocytes system for assessing drug induction.
• Significant induction was observed in both cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase levels.
• Assessment using physiologically based pharmacokinetic modeling enhances the interpretation of drug metabolism.
• Study may enable improved translatability of preclinical findings to clinical settings, highlighting its potential for drug development.