Human milk fat substitutes improve obesity-related NAFLD by enriching LPC 18:2 to activate hepatic GPR119–AMPK signaling

Key Points

• LPC 18:2 enrichment activates GPR119-AMPK signaling, improving hepatic lipid catabolism.
• The primary outcome indicates significant alleviation of diet-induced metabolic impairments in mice.
• This study utilizes a mouse model to explore the effects of human milk fat substitutes on liver health.
• The findings highlight the potential for structured lipids as nutritional interventions for obesity-related liver disease.