Prolonged sedentary behavior in office workers is associated with increased metabolic health risks, including impaired glucose regulation and insulin resistance. While the benefits of structured exercise are well-established, feasible workplace interventions remain limited. This study investigated whether brief hourly micro-exercise breaks could improve metabolic health markers in sedentary office workers in Nanchang, China. A 12-week randomized controlled trial was conducted with 86 sedentary office workers (aged 25–55 years). Participants were randomized to either an intervention group (n = 43) performing 3-minute micro-exercise breaks every hour during workdays, or a control group (n = 43) maintaining usual behavior. Primary outcomes included fasting blood glucose, 2-hour postprandial glucose, and insulin resistance (HOMA-IR). Secondary outcomes included anthropometric measures, blood pressure, lipid profiles, physical activity levels, and work productivity. Seventy-nine participants (91.9%) completed the 12-week assessment. At 12 weeks, the intervention group showed significant improvements from baseline compared to controls in fasting blood glucose (mean difference: -0.31 mmol/L, 95% CI: -0.42 to -0.20, p < 0.001), 2-hour postprandial glucose (mean difference: -0.58 mmol/L, 95% CI: -0.75 to -0.41, p < 0.001), and HOMA-IR (mean difference: -0.42, 95% CI: -0.55 to -0.29, p < 0.001). The intervention group also demonstrated reductions in waist circumference (-2.1 cm, p = 0.001), systolic blood pressure (-3.9 mmHg, p = 0.002), and improvements in HDL-cholesterol (+ 0.1 mmol/L, p = 0.04). Participants reported higher energy levels (+ 1.6 points, p < 0.001) and improved work productivity (+ 1.3 points, p < 0.001). Mean adherence was 82% (range: 65–97%), with 82.5% of participants achieving ≥ 80% adherence. No serious adverse events occurred. Hourly 3-minute micro-exercise breaks represent a feasible and effective strategy for improving metabolic health in sedentary office workers. This simple, equipment-free intervention can be readily implemented in workplace settings to reduce cardiometabolic risk. Not applicable. This study was registered with the Academic Ethics Committee of Nanchang Health Vocational and Technical College (approval number: NCHVC-2024RT-2419) but was not registered in a clinical trial registry as it did not meet the criteria requiring trial registration under Chinese regulations.
Fang et al. (Mon,) studied this question.