GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral Nociception

Key Points

• Visceral nociception is mediated by GPR68, indicating a critical role of this proton-sensing receptor in pain response.
• The study shows that acid exposure activates visceral nociceptive pathways influenced by GPR68 activity.
• Assessment of GPR68 function was performed using various experimental models to explore its role in nociception.
• Findings highlight the potential of GPR68 as a therapeutic target for managing visceral pain conditions.