Prospective serial proteomic analysis uncovers mechanistic pathways of chemotherapy resistance in advanced non-small cell lung cancer

Key Points

• Chemotherapy resistance pathways were uncovered in advanced non-small cell lung cancer, highlighting critical biomarkers.
• The analysis identified specific mechanistic pathways associated with resistance, indicating potential therapeutic targets.
• Observational analysis pinpointed novel proteomic biomarkers linked to decreased treatment efficacy in lung cancer patients.
• These findings support the need for targeted therapies to overcome chemotherapy resistance and improve patient outcomes.