March 3, 2026Journal of bone oncology0 citationsOpen Access

Questionable indication for postoperative radiotherapy after surgery for metastases of the major long bones: A single-centre cohort study of 552 fractures/526 patients

JEJessica Ehne AKAdele Kastensson RWRikard Wedin

Key Points

Tumour related failure risk increased significantly in patients receiving postoperative radiotherapy.
In the prosthesis group, those treated with postoperative radiotherapy experienced more tumour failures than those who did not.
Cohort study analyzing data from 552 fractures across 526 patients revealed these concerning outcomes.
Results suggest caution in recommending universal postoperative radiotherapy for long bone metastases, indicating the need for personalized treatment.

Abstract

In this cohort, PORT was associated with a significantly increased risk of tumour related failure in patients treated with a prosthesis. There was no significant effect in the osteosynthesis subgroup. Our results indicate that there is no clear evidence for the universal use of PORT.

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