SERS fingerprinting of β2-agonists for anti-doping based on Au–COF substrate

Key Points

• Detection methods showed a significant enhancement for β2-agonists using SERS fingerprinting.
• The SERS technique achieved a detection limit of 0.1 ng/mL, showcasing its high sensitivity.
• SERS fingerprinting was performed using an Au–COF substrate, providing a novel approach in anti-doping detection.
• This method may enable more accurate monitoring of performance-enhancing drugs in athletes, enhancing sport integrity.