Next-generation advanced surface plasmon resonance biosensor for dopamine detection with ZnO-ag multilayer design: Machine learning optimization for high sensitivity

Key Points

• Dopamine detection sensitivity is significantly enhanced using the ZnO-Ag multilayer design, leading to better analytical performances.
• The model optimizes sensitivity achieving a detection limit potentially lower than 1 nM, which is crucial for biological applications.
• Machine learning techniques were employed to achieve parameter optimization, improving the sensor's overall performance.
• These findings highlight the potential for advanced biosensors in real-time monitoring of neurochemical changes.