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Machine learning on dynamic functional connectivity: Promise, pitfalls, and interpretations | Synapse
March 3, 2026
Open Access
Machine learning on dynamic functional connectivity: Promise, pitfalls, and interpretations
JD
Jiaqi Ding
University of North Carolina at Chapel Hill
TD
Tingting Dan
University of North Carolina at Chapel Hill
ZW
Ziquan Wei
University of North Carolina at Chapel Hill
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Key Points
Machine learning shows potential to enhance our understanding of dynamic functional connectivity, yet its application may lead to misinterpretations.
Key findings emphasize the complexity and variability in neural connections, making accurate modeling crucial for research success.
Dynamic analysis of brain data using advanced algorithms reveals the need for careful consideration of results and methodologies.
Challenges exist in ensuring reliable conclusions from machine learning models in this context, indicating a need for cautious interpretation.
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Ding et al. (Thu,) studied this question.
synapsesocial.com/papers/69a76749badf0bb9e87e04df
https://doi.org/https://doi.org/10.1016/j.ins.2026.123184