Targeting muscle-bone crosstalk with hormone-like peptides: Systems approach reveals RGHGP-mediated suppression of LAMB1-MAPK osteoclastogenesis

Key Points

• Suppression of osteoclastogenesis is observed with hormone-like peptide RGHGP.
• LAMB1 and MAPK pathways are crucial in osteoclast formation and activity.
• Utilizing a systems approach highlights the role of muscle-bone crosstalk in regulating bone health.
• The findings may suggest new therapeutic targets for bone-related disorders.