Epidemiological and Genomic Insights into Linezolid-Non-Susceptible Enterococci in Pediatric Patients

Key Points

• Enterococci showed reduced susceptibility to linezolid, indicating a significant factor in treatment outcomes.
• The analysis included multi-center data from 350 pediatric patients over three years, revealing alarming resistance patterns.
• This observational analysis utilized genomic insights to understand the resistance mechanisms of enterococci.
• Findings may enable better management strategies for treating infections caused by linezolid-resistant enterococci in children.