Stereo-encephalography-guided multi-lead deep brain stimulation for treatment-refractory obsessive compulsive disorder – Study design and individualized surgical targeting approach

Key Points

• Deep brain stimulation shows promise in reducing obsessive compulsive disorder symptoms with personalized targeting.
• In a cohort with treatment-refractory OCD, approximately 70% of participants reported symptom improvement after surgery.
• Stereoelectroencephalography-guided analysis informs individualized targeting for deep brain stimulation to optimize outcomes.
• This innovative approach may enable more effective interventions for OCD, warranting further investigation in diverse settings.