March 3, 20260 citationsOpen Access

Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort

GLGiulia LorenzonKarolinska Institutet GGGemma García-LluchUniversidad Cardenal Herrera CEU GCGillian CoughlanBrigham and Women's Hospital

Key Points

Late-life cerebrovascular health in women appears to be supported by extended exposure to estrogen.
The analysis highlights the potential of genotype-specific neuroprotective effects of estrogen on brain health.
Population-based data from the Gothenburg H70-1944 Birth Cohort informed these findings on hormonal therapy.
Future research calls for clarifying estrogen's long-term impact on cognition to improve prevention guidelines.

Abstract

Extended estrogen exposure throughout life-both endogenous and exogenous-appear to support late-life cerebrovascular health in women, with potential genotype-specific neuroprotective effects. Given the current absence of sex-specific prevention guidelines for cognitive disorders, future research should clarify estrogen's longterm impact on brain health and cognition to inform personalized medicine.

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