Pirfenidone ameliorates dexamethasone-induced steatohepatitis and vascular resistance in rats

Key Points

• Pirfenidone significantly reduces the severity of steatohepatitis in rats treated with dexamethasone.
• In this study, vascular resistance improved alongside liver health after pirfenidone treatment.
• Analysis involved dexamethasone-induced steatohepatitis models in rats, highlighting therapeutic potential.
• These findings suggest that pirfenidone may offer protection in cases of drug-induced liver damage, warranting further investigation.