Gemini surfactant-stabilized cubosomes for enhanced topical delivery of 5-fluorouracil in cutaneous squamous cell carcinoma

Key Points

• Enhanced delivery efficiency of 5-fluorouracil with gemini surfactant-stabilized cubosomes was observed.
• A significant improvement in local drug concentration was achieved, indicating effective treatment for skin cancer.
• Assessment involved innovative formulation tactics using cubosomes as delivery systems.
• May enable greater therapeutic effects in skin cancer treatments while minimizing systemic side effects.