Effect of tablet press residence time distribution on material traceability in a continuous direct compression process via mini-batch blending – part 1: corroboration and application

Key Points

• Material traceability is influenced by the residence time distribution during compression, enhancing process reliability.
• Data from mini-batch blending demonstrates significant effects on traceability across various tablet press conditions.
• The study utilized an observational strategy to explore the relationship between composition and processing time.
• Highlights the need for further investigation into optimizing residence time to improve pharmaceutical manufacturing processes.