Genetically encoded biosensor of apoptosis and necrosis reveals the dynamics and biphasic cytotoxicity by Anti-EGFR CAR-T cells

Key Points

• Cytotoxicity of anti-EGFR CAR-T cells demonstrates a biphasic response, highlighting the complexities of treatment.
• The genetically encoded biosensor provides real-time insights into the dynamics of apoptosis and necrosis.
• Cytotoxicity levels peaked at distinct phases, suggesting a non-linear response to anti-EGFR therapy.
• This innovative methodology may allow for improved personalization and efficacy in CAR-T cell therapies.