Breviscapine inhibits the proliferation and immune escape of diffuse large B-cell lymphoma cells by regulating JAK2/STAT3/PD-L1 pathway.

Key Points

• To explore the effects of breviscapine on the growth and immune escape of DLBCL cells through specific molecular pathways.
• In vitro experiments on DLBCL cell lines.
• Assessment of cell proliferation and immune escape mechanisms.
• Analysis of JAK2/STAT3/PD-L1 pathway activity.
• Breviscapine significantly inhibited DLBCL cell growth.
• It effectively reduced the immune escape of these cells.
• The regulation of JAK2/STAT3/PD-L1 pathway was demonstrated.