Introduction The majority of observational studies approved that regular consumption of vitamin E would decrease the risk of cardiovascular events. However, a great number of randomised trials do not support this idea and dismiss the beneficial effect of vitamin E in reducing heart disease risk factors. Methods To test this hypothesis and identify whether vitamin E supplementation can reduce the risks of cardiovascular diseases, we organised a systematic review to reach out relevant articles. Insert the authors' criteria for inclusion and exclusion of studies; 58 papers were remained in the review. Results Some of the studies revealed a significant role of vitamin E in preventing CVD, while almost all of the trials suggested no beneficial impact of vitamin E on cardiovascular outcomes. Thus, there is a need for further studies to be conducted in the field. Conclusion It is recommended to critically review the results of randomised trials based on a wide range of different parameters, including the form of vitamin E, the duration and dosage of vitamin E consumption, and the synergetic effects of vitamin E with other antioxidants or medication. The intervention studies also need to be considered in terms of specific clinical settings and be improved through successful study designs.
Sharifi et al. (Mon,) studied this question.