What question did this study set out to answer?

The study aims to explore the association between the MMP-3 genotype and the risk of developing pterygium.

March 5, 2026Cancer Genomics & Proteomics0 citationsOpen Access

Unravelling the Contribution of Matrix Metalloproteinase-3 Genotype-Phenotype to Pterygium Risk

HCHUNG-CHIH CHENChina Medical University NHNing-Yi Hsia CTCHUNG-LIN TSAIChina Medical University

Key Points

The study aims to explore the association between the MMP-3 genotype and the risk of developing pterygium.
Genetic analysis focusing on MMP-3 rs3025058 variant
Assessment of its role in susceptibility to pterygium
Evaluation of extracellular matrix (ECM) regulation.
Identified MMP-3 rs3025058 as a potential genetic biomarker for pterygium risk
Found evidence of ECM dysregulation linked to this genotype
Suggested implications for disease progression and risk assessment.

Abstract

MMP-3 rs3025058 may serve as a genetic biomarker for pterygium susceptibility prediction, potentially contributing to ECM dysregulation and disease progression.

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