What question did this study set out to answer?

This research aims to examine the changes in hyaluronan and associated biomarkers in patients undergoing gastric bypass surgery.

March 5, 2026Obesity Surgery2 citationsOpen Access

Hyaluronan and Associated Biomarkers: A Longitudinal Cohort Study in Patients with Obesity Following Gastric Bypass Surgery

DTDavid ThalénUmeå University UHUrban HellmanUmeå University JWJeff WennerlundUmeå University

Key Points

This research aims to examine the changes in hyaluronan and associated biomarkers in patients undergoing gastric bypass surgery.
Longitudinal cohort design
Assessment of biomarker levels preoperatively and at multiple postoperative intervals
Statistical analyses to evaluate changes in biomarker concentrations
39.6% of patients had elevated preoperative hyaluronan levels (> 120 ng/ml)
Significant decreases in hyaluronan, CD44, MMP-2, MMP-9, TNF-α, IL-1β, and IL-6 were observed immediately post-surgery
Patients with baseline hyaluronan ≥ 120 ng/ml had a sustained decrease at 6 months

Abstract

Preoperatively, an elevated HA-concentration (> 120 ng/ml) was seen in 39.6% of the study population. From baseline to day of surgery, we found a statistically significant decrease (p 120ng/ml) showed a sustained reduction. The postoperative increase of MMP-2 suggests a continuous remodeling of the extracellular matrix.

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