Microenvironment-Responsive Hydrogel with Photothermal, Antioxidant, and Neuroregenerative Functions for Diabetic Chronic Infectious Wound Healing

Key Points

• To develop a multifunctional hydrogel aimed at improving healing in diabetic chronic infectious wounds.
• Constructed a hydrogel using dynamic boronate crosslinking.
• Analyzed hydrogel's responsiveness to microenvironmental factors.
• Evaluated photothermal, antioxidant, and neuroregenerative properties.
• Hydrogel effectively reduced oxidative stress in wounds.
• Promoted vascularization and tissue regeneration.
• Showed potential to mitigate persistent infections in diabetic wounds.