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Synapse
March 5, 20260 citations

In the Era of mpMRI and PSMA PET/CT: Does Digital Rectal Examination Still Matter?

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AEAnil EkerFDFatih DilerSTSelda Yilmaz Tatar

Key Points

  • To evaluate the role of digital rectal examination in the context of advanced imaging techniques for prostate cancer diagnosis.
  • Comparison of DRE findings with mpMRI and PSMA PET/CT results.
  • Evaluated the clinical implications of DRE in identifying high-risk prostate cancer.
  • Analysis of DRE as a risk stratification tool rather than a primary screening method.
  • DRE remains a valuable tool for identifying advanced prostate cancer.
  • When combined with mpMRI and PSMA PET/CT, DRE enhances clinical assessment and risk stratification.
  • Continued use of DRE is supported in the modern diagnostic workflow for prostate cancer.

Abstract

Despite the rise of advanced imaging techniques, DRE remains a valuable adjunctive tool in identifying high-risk and advanced PCa. When interpreted alongside mpMRI and PSMA PET/CT findings, DRE provides additional clinical insight, supporting its continued role in risk stratification rather than screening in the modern diagnostic workflow.

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Cite This Study

Eker et al. (2026) studied this question.

synapsesocial.com/papers/69a91df9d6127c7a504c1561https://doi.org/10.1002/pros.70151
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Context-dependent role of digital rectal examination in a contemporary prostate biopsy cohort: differential predictive value with and without multiparametric magnetic resonance imaging2026
  2. 2Re-evaluating the role of digital rectal examination in prostate cancer diagnosis in the era of modern MRI2024
  3. 3Sensitivity and Specificity of Digital Rectal Examination for the Diagnosis of Prostate Cancer at the Kano Teaching Hospital - A Comparative Analysis2024 · 1 citations
  4. 4Digital rectal examination in rectal cancer response assessment: clinical performance and the need for standardized reporting2026
  5. 5Addition of MRI or DRE to clinical data and risk prediction for clinically significant prostate cancer.2024