A randomized double-blind placebo-controlled trial of oliceridine, a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy.

Key Points

• The aim is to evaluate the efficacy and safety of oliceridine as an analgesic for managing pain post-bunionectomy.
• Conducted a randomized double-blind placebo-controlled trial
• Included Korean patients undergoing bunionectomy
• Administered oliceridine to assess pain relief
• Monitored for adverse events
• Oliceridine provided rapid and significant pain relief
• No serious adverse events were reported
• Support for oliceridine as a well-tolerated analgesic option