What question did this study set out to answer?

The aim is to evaluate the expression of endoplasmic reticulum stress markers in endometrial cancer and their correlation with clinical features and survival.

March 6, 20260 citationsOpen Access

Immunohistochemical Expression of Endoplasmic Reticulum Stress Markers and their Association With Clinicopathological Characteristics and Survival Outcomes in Endometrial Cancer.

View Full Paper

SFStefanos FlindrisAristotle University of Thessaloniki CMCHRYSOULA MARGIOULA-SIARKOUAristotle University of Thessaloniki CGCHRYSOULA GOUTAIppokrateio General Hospital of Thessaloniki

Key Points

The aim is to evaluate the expression of endoplasmic reticulum stress markers in endometrial cancer and their correlation with clinical features and survival.
Analyzed the expression of IRE1 and PERK in endometrial cancer samples.
Correlated marker expression with clinicopathological characteristics.
Assessed the prognostic value of these markers for survival outcomes.
IRE1 and PERK expression is significantly up-regulated in endometrial cancer.
Both markers correlate with aggressive clinicopathological features.
No independent prognostic value for survival outcomes was found.

Abstract

IRE1 and PERK expression is up-regulated in endometrial cancer and correlates with selected clinicopathological features, particularly those linked to aggressive disease. However, neither marker demonstrated independent prognostic value for survival outcomes. Further studies are warranted to clarify the role of ER stress pathways in EC biology and their potential implications for risk stratification and targeted therapy.

问 AI

Bookmark

View Full Paper

问 AI

Bookmark

View Full Paper

Immunohistochemical Expression of Endoplasmic Reticulum Stress Markers and their Association With Clinicopathological Characteristics and Survival Outcomes in Endometrial Cancer.

Key Points

Abstract

Cite This Study

Also Consider

Also Consider