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March 6, 2026Inflammation5 citationsOpen Access

METTL3-Mediated m6A Regulation of CircINTS4/miR-146b-3p Axis in Rheumatoid Arthritis

SLShu LiMZMengYu ZhangSLSiyu Liang

Key Points

  • Examine how METTL3-mediated m6A modification affects the circINTS4/miR-146b-3p axis in rheumatoid arthritis and its implications for disease severity.
  • Investigated METTL3 function in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)
  • Analyzed circINTS4 role as a sponge for miR-146b-3p
  • Assessed the correlation between circINTS4 and RA disease severity
  • CircINTS4 significantly modulates RA-FLS pathogenicity
  • miR-146b-3p acts as a target of circINTS4, influencing inflammatory responses
  • Demonstrated the potential of circINTS4 as a biomarker for RA severity

Abstract

Our findings reveal that METTL3-mediated m6A modification regulates the circINTS4/miR-146b-3p axis, modulating RA-FLS pathogenicity and inflammatory responses. CircINTS4 acts as a molecular sponge for miR-146b-3p and serves as a promising biomarker for RA disease severity. This study provides new insights into the role of m6A methylation and circRNA-miRNA networks in RA, highlighting their potential as diagnostic and therapeutic targets.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff5927ahttps://doi.org/10.1007/s10753-026-02484-9
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