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March 6, 2026PLoS Biology0 citationsOpen Access

Developing monoclonal antibody therapies for measles could lead to adverse pathogen evolution

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DKDavid A. Kennedy

Key Points

  • The aim is to examine the implications of monoclonal antibody therapies for measles and their effect on virus evolution.
  • Analysis of monoclonal antibody therapies in the context of measles
  • Review of recent measles virus resurgence and vaccination effectiveness
  • Consideration of evolutionary biology regarding pathogen adaptation.
  • Monoclonal antibody therapies could facilitate measles virus evolution.
  • Evolution of the virus might reduce vaccine effectiveness.
  • Potential adverse effects may outweigh the benefits of these therapies.

Abstract

Monoclonal antibody therapies are being developed to treat measles in response to its recent resurgence. These therapies risk driving measles virus evolution in ways that might undermine the protection offered by vaccination, outweighing potential benefits.

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Cite This Study

David A. Kennedy (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff592efhttps://doi.org/10.1371/journal.pbio.3003701
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