Effect of italicFufang Shenqi Granule/italic （复方参芪颗粒） on Th2 cytokines via modulating TSLP in a rat model of allergic rhinitis

Key Points

• To investigate the impact of Fufang Shenqi Granule on TSLP expression and Th2 cytokine levels in a rat model of allergic rhinitis.
• SD rats were divided into five groups: control, model, positive drug, and three doses of Fufang Shenqi Granule.
• A rat model of allergic rhinitis was established using ovalbumin (OVA) induction.
• Post-treatment, behavioral scores were assessed, and serum levels of IL-4, IL-5, IL-13, and OVA-sIgE were measured using ELISA.
• Histopathological changes in nasal mucosa were examined via HE staining.
• TSLP protein expression was detected using immunohistochemistry and Western blot.
• Model group rats showed significantly increased behavioral scores compared to controls (P<0.01).
• Histological analysis indicated nasal mucosa thinning, loss of cilia, and increased eosinophils.
• Serum levels of IL-4, IL-5, IL-13, and OVA-sIgE were significantly elevated (P<0.05).
• TSLP protein expression was significantly increased in the model group (P<0.05).
• Fufang Shenqi Granule treatment led to reduced scores, improved pathology, and lower cytokine levels in a dose-dependent manner (P<0.05).