ARID4B Promotes Lung Adenocarcinoma Malignancy by Activating GPRC5C transcription via Histone H1 Displacement

Key Points

• This research investigates the role of ARID4B in enhancing lung adenocarcinoma malignancy through GPRC5C activation.
• Examined the role of ARID4B in transcription regulation
• Studied the activation of GPRC5C
• Evaluated effects on epithelial-mesenchymal transition (EMT) and stemness
• ARID4B was found to activate GPRC5C transcription
• Activation led to increased malignancy in lung adenocarcinoma
• GPRC5C activation was linked to enhanced EMT and cancer stemness