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March 7, 2026Cell Reports3 citationsOpen Access

Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

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SCShixin CuiNBNicole L. BatenburgYCYan Coulombe

Key Points

  • This research focuses on the function of ASCC3 helicase in unwinding DNA during replication stress.
  • Assessment of ASCC3 activity in DNA unwinding
  • Analysis of replication fork stability
  • Evaluation of stress-response pathways
  • ASCC3 effectively unwinds DNA at stalled replication forks
  • Enhanced replication stress response observed in the presence of ASCC3
  • Inhibition of ASCC3 leads to increased DNA damage

Abstract

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

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Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/69abc1015af8044f7a4e9aa4https://doi.org/10.1016/j.celrep.2026.117051
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