What does this research mean for the field?

Grifola frondosa polysaccharide (GFP) ameliorates adenine-induced chronic kidney disease (CKD) in mice by inhibiting the TGF-β1/Smad signaling pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to explore the protective effects of Grifola frondosa polysaccharide against chronic kidney disease (CKD) induced by adenine in mice.

March 7, 20260 citations

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Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.

HSHuanjun Shi LSLian Shi JLJing Li

Key Points

The study aims to explore the protective effects of Grifola frondosa polysaccharide against chronic kidney disease (CKD) induced by adenine in mice.
Administered Grifola frondosa polysaccharide to mice with adenine-induced CKD.
Evaluated antioxidant, anti-inflammatory, and anti-fibrotic activities.
Assessed the involvement of the TGF-β1/Smad signaling pathway.
Grifola frondosa polysaccharide significantly reduced kidney damage markers.
Treatment suppressed TGF-β1/Smad signaling pathway activation.
Demonstrated antioxidant and anti-inflammatory effects in treated mice.

Abstract

Our findings demonstrated that GFP exerted potent renoprotection against adenine-induced CKD in mice, mediated by its antioxidant, anti-inflammatory, and anti-fibrotic activities. The anti-fibrotic mechanism was mediated via the suppression of the TGF-β1/Smad signaling pathway. These results highlighted the potential of GFP as functional food ingredients or adjunctive therapeutic agents for preventing and treating CKD and its complications. © 2026 Society of Chemical Industry.

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Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.

Key Points

Abstract

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